Poster électronique

Comparaison intra-individuelle en ARM avec Dotarem® et Gadovist® dans le diagnostic des artériopathies périphériques abdominales
S. Haneder (1), UI. Attenberger (1), S. Schönberg (1), C. Loewe (2), J. Arnaiz (3), H. Michaely (1) - (1) Mannheim - Allemagne, (2) Vienne - Autriche, (3) Santander - Espagne
Congrès 2011
Résumé
Objectifs
Comparer la performance diagnostique de l'angiographie par résonance magnétique (ARM) avec Dotarem® (0,5M) et Gadovist® (1,0M) à 3 Tesla avec la technique de la table mobile continue (TimTrio).
Matériels et méthodes
Etude monocentrique en cross-over, randomisée. Vingt patients (61,5±8,1 ans) ayant une artériopathie oblitérante (stade II / III) ont reçu une injection de 0,1 mmol/kg de Dotarem® et de Gadovist®. Le critère principal était la qualité globale de l’image évaluée en aveugle par 4 experts indépendants. Les principaux critères secondaires étaient la confiance diagnostique, l’intensité du signal (SNR/CNR), les mesures de sténoses significatives (>50%), et la tolérance.
Résultats
La qualité globale de l’image a étéévaluée plus fréquemment excellente/plus que adéquate avec Dotarem® comparée au Gadovist® (100% vs 78,6%, 100% vs 92,9%, 100% vs 85,7%, 100% vs 85,7%). Des résultats similaires ont été observés pour la confiance diagnostique. Des valeurs supérieures de SNR/CNR ont été obtenues avec Gadovist® par rapport au Dotarem® (26,1/23,4 vs 22,7/20,2). Pour les critères secondaires, aucune différence entre les produits n'a été observée. Aucun effet indésirable signalé.
Conclusion
Alors qu'un rehaussement vasculaire plus intense a été observé avec Gadovist®, Dotarem® a été mieux évalué en terme de qualité d’image globale et confiance diagnostique.
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2017-04-12 09.51 :
Lisa Calabrese

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