Poster électronique

Intérêt de l'IRM de diffusion dans la distinction des différentes composantes des tumeurs hépatiques
M. Wagner (1), S. Doblas (1), JL. Daire (1), N. Haddad (1), H. Leitao (2), P. Garteiser (1), V. Vilgrain (1), R. Sinkus (1), B. Van Beers (1) - (1) Clichy - France, (2) Coimbra - Portugal
Congrès 2011
Poster primé par le jury
Poster
3,3
6 votes.
Vu 496 fois.
Résumé
Objectifs
Evaluer si l'IRM de diffusion avec multiples valeurs de b et mesure du coefficient apparent de diffusion ADC, du coefficient de diffusion pure D, du coefficient de diffusion liéà la perfusion D* et de la fraction de perfusion f permet de différencier les portions viable, fibreuse et nécrosée des tumeurs hépatiques.
Matériels et méthodes
88 patients ont été inclus prospectivement et ont bénéficié d'une IRM de diffusion avec 11 valeurs de b (0 à 500 s/mm2) et d'une acquisition dynamique 3DT1GRE après injection de chélates de gadolinium. Les paramètres D, D*, f (modèle biexponentiel) et ADC (modèle monoexponentiel) ont été calculés. En fonction de leur rehaussement, les lésions ont été subdivisées en régions viables, fibreuses et nécrosées.
Résultats
D diffère significativement (p<0,05) entre les 3 régions, viable, fibreuse et nécrosée (1.28+/-0.35x10-3, 1.47+/-0.29x10-3 et 1.85+/-0.61x10-3 mm2/s). La fraction de perfusion f est significativement inférieure dans les régions nécrosées (13%+/-5%) par rapport aux régions viables (22%+/-9%, p<0.05), mais f ne diffère pas significativement entre les régions fibreuses et les deux autres régions. Aucune différence significative n'est retrouvée pour D* et ADC entre les trois régions.
Conclusion
Les régions viables, fibreuses et nécrosées des tumeurs hépatiques peuvent être différenciées par D et non par les autres paramètres.
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2017-08-31 23.04 :
Lisa Calabrese

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2017-04-12 15.21 :
Scott Jones

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