Poster électronique

Cartographies T1/T2/T2* sur un modèle animal de fibrose myocardique diffuse : corrélation aux données histopathologiques
J. Caudron, P. Mulder, L. Nicol, V. Lefebvre, V. Richard, C. Thuillez, F. Bauer, JN. Dacher - Rouen - France
Congrès 2011
Résumé
Objectifs
Evaluer in vivo les modifications des temps de relaxation T1/T2/T2* sur un modèle animal de fibrose myocardique diffuse, le rat spontanément hypertendu (SHR).
Matériels et méthodes
Cinq groupes de rats ont été explorés sur une IRM petit animal 4.7 Tesla. Groupe 1 : témoins Wistar ; Groupe 2 : SHR 12 semaines non traités ; Groupe 3 : SHR 24 semaines traités pendant 12 semaines par un inhibiteur de l'aldostérone synthase ; Groupe 4 : SHR 24 semaines traités pendant 1 semaine ; Groupe 5 : SHR 24 semaines non traités. Les temps de relaxation T1/T2/T2* ont été calculés. Le contenu en collagène du myocarde a étéévalué après sacrifice en utilisant la coloration rouge Sirius, puis corrélé aux valeurs des temps de relaxation.
Résultats
Une augmentation significative des valeurs du T1 myocardique a été mise en évidence chez les SHR. Les valeurs du T1 myocardique s'échelonnaient de 1211,3±12,9 ms pour le groupe témoin ayant le contenu fibreux le plus faible en histologie, à 1258,5±17,3 ms pour le groupe SHR 24 semaines non traité ayant le contenu fibreux le plus élevé (p<0,0001). Les valeurs du T1 myocardique étaient corrélées de façon significative au contenu fibreux histopathologique (R=0,71, p<0,0001).
Conclusion
L'augmentation du contenu fibreux myocardique s'accompagne d'une augmentation des valeurs du T1 myocardique.
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2018-09-09 17.48 :
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