Poster électronique

Définir les critères de la réponse tumorale : les limites et les avantages des critères RECIST
M. Nadrljanski, Z. Milosevic, N. Borojevic - Belgrade - Serbie
Congrès 2010
Résumé
Objectifs
L'objectif était d'analyser l'applicabilité des critères RECIST pour évaluer l’activité antitumorale chez des sujets atteints de carcinome hépatocellulaire non résécable traités par un inhibiteur oral multikinase.
Matériels et méthodes
Si l'on appliquait les critères RECIST, l’activité antitumorale avec des nouveaux agents thérapeutiques, ne serait pas apparente, en dépit des avantages en termes de critères d’évaluation principaux : la survie globale et la survie sans progression. L'étude contrôlée, randomisée, en double aveugle, de phase III comparant l’effet de soins supportifs plus sorafénib ou placebo chez des sujets atteints de carcinome hépatocellulaire (CHC) non résécable, a été analysée.
Résultats
Le sorafénib a démontré un bénéfice de survie en dépit de l’absence de réduction tumorale importante. Bien que le temps de progression radiologique était de 5,5 mois dans le groupe sorafénib et 2,8 mois dans le groupe placebo (p < 0,001), il n’y avait que les neuf réponses selon les critères RECIST : sept sujets dans le groupe sorafénib (2,3 %) et deux sujets dans le groupe placebo (0,7 %), qui présentaient tous une réponse partielle.
Conclusion
Les critères RECIST ne sont pas universellement applicables à tous les types de cancer et classes de médicaments, en s’appuyant sur le changement de taille des lésions pour évaluer la réponse thérapeutique.
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2017-04-11 11.40 :
Ann Tabares

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2017-04-11 08.47 :
Shana Phillips

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