Poster électronique

Embolisation et désendothélialisation par gel de Chitosan et STS : faisabilité sur modèle animal
P. Chabrot (1), P. Delli-Fraine (2), A. Fatimi (2), S. Lerouge (2), G. Soulez (2) - (1) Clermont-Ferrand - France, (2) Montréal - Canada
Congrès 2010
Résumé
Objectifs
Comparer l'efficacité d'une embolisation artérielle par hydrogel de chitosan sans et avec sclérosant (STS) sur un modèle animal.
Matériels et méthodes
Les artères auriculaires droite et gauche de 19 lapins ont été cathétérisées pour permettre l'injection de 0,6 ml de chitosan (OCh, n = 14) d'un côté et du serum physiologique (OSal, n = 2), ou du chitosan et STS 1 % (OCs 1, n = 6), ou du chitosan et STS 3 % (OCs3, n = 6) du côté controlatéral. La longueur initialement embolisée (Lembol) et le pourcentage de recanalisation (% recanal) étaient évalués cliniquement et par Laser Doppler à 1,7, 14 et 30 jours post-embolisation. Une analyse histologique était effectuée après sacrifice à 30 jours évaluant la destruction endothéliale.
Résultats
La Lembol était mesurée respectivement à 21+/-8,32+/-18,40+/-6, et 56+/-9 mm respectivement pour OSal, OCh, OCs1 et OCs3. La Lembol était significativement plus importante avec OCs 3 qu'avec Och (p < 0,01). Après 30 jours, l'ensemble des OSal était reperméabilisé. Le % recanal était de 17,8+/-14,6, de 25,6+/-34,3 %, et 22,5+/-15 % respectivement pour OCh, OCs1 et OCs3 sans différence entre les groupes.
Conclusion
Notre travail illustre la faisabilité d'une embolisation par gel de chitosan +/- STS. La viscosité du chitosan-STS 3 % permet d'obtenir un meilleur contrôle de la longueur d'embolisation initiale sans différence de recanalisation.
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