Poster électronique

Iopamidol faiblement osmolaire et iodixanol iso-osmolaire : fréquence cardiaque au scanner –étude prospective randomisée multicentrique
C. Chartrand-Lefebvre (1), CS. White (2), J. Prenovault (1), J. Chalaoui (3), L. Samson (1), S. Bhalla (4), WW. Mayo-Smith (5), KH. Vydareny (6), JA. Soto (7), G. Soulez (1) - (1) Montréal - Canada, (2) Baltimore - Etats-Unis, (3) Outremont - Canada, (4) St-Louis - Etats-Unis, (5) Providence - Etats-Unis, (6) Atlanta - Etats-Unis, (7) Boston - Etats-Unis
Congrès 2010
Poster primé par le jury
Résumé
Objectifs
Comparer l'effet sur la fréquence cardiaque (FC) entre l'administration d'iopamidol (faiblement osmolaire) et d'iodixanol (iso-osmolaire) en angioscan thoracique, sans synchronisation ECG.
Matériels et méthodes
Etude prospective multicentrique randomisée, comparant iopamidol-370 et iodixanol-320, dans huit centres nord-américains (130 patients; 54M; âge moyen 52) avec suspicion clinique d'embolie pulmonaire. Soixante trois patients ont reçu l'iopamidol-370 et 67 patients l'iodixanol-320 (80 ml iv, 4ml/s). La tomodensitométrie (64-coupes) se faisait en apnée, sans bêta-bloqueurs. La FC pré-contraste (bpm) était comparée à la FC maximale post-contraste (test t non pairé et test 2, pour variables continues et ordinales, respectivement).
Résultats
La FC pré-contraste était similaire dans les deux groupes (iopamidol : moyenne 81.3 ; iodixanol : moyenne 76,9) (p=0,16), et a faiblement augmenté dans les deux groupes après l'injection. La FC moyenne maximale post-contraste était 86,8 pour l'iopamidol, et 82,4 pour l'iodixanol (p=0,16). Le changement moyen pré- et post-contraste était 5,4 pour iopamidol et iodixanol, identique entre les deux groupes (p=0,72).
Conclusion
La fréquence cardiaque est faiblement augmentée par l'iopamidol-370 et l'iodixanol-320 en angioscan pulmonaire. Cette augmentation est similaire pour l'iopamidol-370 et l'iodixanol-320. L'effet sur la fréquence cardiaque ne devrait pas être une barrière à l'utilisation d'un agent faiblement osmolaire en tomodensitométrie cardiaque avec synchronisation ECG.
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2017-12-11 04.16 :
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2010-10-22 15.22 :
GAILLARD Sophie

Ce poster est très clair et très intéressant et c'est une très belle étude. Je serais très intéressée que vous m'en adressiez une copie électronique. Vous remerciant par avance, Bien cordialement, Dr Sophie Gaillard, Responsable Pharmacovigilance, GUERBET
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