Poster électronique

Evaluation et suivi de la trophicité musculaire par IRM
J. Bocquet (1), P. Cambefort (2), G. De Fleurian (3), C. Bocquet (1) - (1) Fort De France - France, (2) Toulon - France, (3) Courbevoie - France
Congrès 2009
Résumé
Objectifs
Permettre un suivi simple par IRM de la trophicité musculaire dans le cadre d’essais thérapeutiques.
Matériels et méthodes
Des séquences T1 ont été réalisées en coupes axiales de 5 mm d'épaisseur au niveau des jambes chez 6 patients présentant une myopathie de la loge antérieure de jambe à M0, M1, M3, M6, M9 et M12. Des extensions au logiciel libre et gratuit de traitement d'images ImageJ ont été développées afin de : délimiter les limites du volume d'intérêt, définir coupe par coupe des zones d'intérêt dans le muscle sain, et dissocier les voxels selon l'intensité du signal en graisse, muscle ou fascias. Cette dissociation est réalisée automatiquement par normalisation par rapport à l'air périphérique de signal nul et au voxel de plus haute intensité de la pile de coupes, de signal graisseux.
Résultats
La normalisation permet la reproductibilité des mesures dans le temps. La concordance inter et intra observateurs apparaît également bonne dans les limites du contourage manuel. La création d'extensions au programme ImageJ permet un traitement rapide des acquisitions et une multiplication du nombre de mesures réduisant les biais induits par ce contourage manuel.
Conclusion
Nous disposons d'un outil simple permettant l'étude de volumes complexes et une bonne reproductibilité des mesures dans le temps afin de suivre la trophicité musculaire en particulier lors d'essais thérapeutiques.
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2016-03-24 03.03 :
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2010-04-27 13.26 :
Créteur

Très intéressant et bien présenté.

2009-10-19 13.40 :
mompoint

merci

2009-10-18 17.55 :
delphine

super

2009-10-16 12.37 :
CABROL

Bien
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